The effect of strontium-substituted hydroxyapatite coating on implant fixation in ovariectomized rats

被引：312

作者：

Li, Yunfeng ^{[1
]}

Li, Qing ^{[2
]}

Zhu, Songsong ^{[1
]}

Luo, En ^{[1
]}

Li, Jihua ^{[1
]}

Feng, Ge ^{[1
]}

Liao, Yunmao ^{[1
]}

Hu, Jing ^{[1
]}

机构：

[1] Sichuan Univ, State Key Lab Oral Dis, Dept Oral & Maxillofacial Surg, W China Coll Stomatol, Chengdu 610041, Peoples R China

[2] Peking Univ, Dent Ctr 2, Sch Stomatol, Beijing 100101, Peoples R China

来源：

BIOMATERIALS | 2010年 / 31卷 / 34期

关键词：

Hydroxyapatite; Strontium; Surface coating; Osteoporosis; Osseointegration; POSTMENOPAUSAL OSTEOPOROSIS; TRABECULAR BONE; DRESS SYNDROME; CORTICAL BONE; IN-VITRO; RANELATE; CEMENT; OSTEOCLAST; OSTEOBLAST; STRENGTH;

D O I：

10.1016/j.biomaterials.2010.07.112

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

This study was designed to investigate the effects of strontium-substituted hydroxyapatite coatings with 10 mol% Ca2+ replaced by Sr2+ (10% SrHA) on implant fixation in ovariectomized (OVX) rats. Coatings of HA and 10%SrHA were prepared on the surface of titanium implant using sol-gel dip methods, and then characterized by Scanning Electron Microscope, Atomic Force Microscope, X-ray diffraction, X-ray Photoemission Spectroscopy, and an automatic scratch tester. Twelve weeks after bilateral ovariectomy, twenty OVX rats accepted implant insertion in the proximal tibiae, half with HA-coated implants and the other half with 10% SrHA coated implants. After 12-week healing period, 10% SrHA coated implants revealed improved osseointegration compared to HA, with the bone area ratio and bone-to-implant contact increased by 70.9% and 49.9% in histomorphometry, the bone volume ratio and percent osseointegration by 73.7% and 45.2% in micro-CT evaluation, and the maximal push-out force and ultimate shear strength by 107.2% and 132.9% in push out test. These results demonstrated that 10% SrHA coatings could enhance implant osseointegration in OVX rats, and suggested the feasibility of using SrHA coatings to improve implant fixation in osteoporotic bone. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：9006 / 9014

页数：9

共 45 条

[1]

Histomorphometric and μCT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate [J].