2-Butoxyethanol model of haemolysis and disseminated thrombosis in female rats: a preliminary study of the vascular mechanism of osteoarthritis in the temporomandibular joint

被引：6

作者：

Amir, G. ^{[1
,2
]}

Goldfarb, A. W. ^{[2
,3
]}

Nyska, M. ^{[4
]}

Redlich, M. ^{[5
]}

Nyska, A. ^{[6
]}

Nitzan, D. W. ^{[7
]}

机构：

[1] Hadassah Med Ctr, Dept Pathol, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Hadassah Med Sch, IL-91010 Jerusalem, Israel

[3] Hadassah Med Ctr, Dept Haematol, IL-91120 Jerusalem, Israel

[4] Sapir Med Ctr, Dept Orthopaed Surg, IL-95847 Kefar Sava, Israel

[5] Hebrew Univ Jerusalem, Hadassah Sch Dent Med, Dept Orthodont, IL-91120 Jerusalem, Israel

[6] Tel Aviv Univ, Sackler Sch Med, IL-36576 Timrat, Israel

[7] Hebrew Univ Jerusalem, Hadassah Sch Dent Med, Dept Oral & Maxillofacial Surg, IL-91120 Jerusalem, Israel

来源：

BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY | 2011年 / 49卷 / 01期

关键词：

2-Butoxyethanol; Animal model; Thrombosis; Haemolysis; Osteoarthritis; Temporomandibular joint; SICKLE-CELL-DISEASE; BONE; ARTHRITIS; CARTILAGE; NECROSIS; ANEMIA;

D O I：

10.1016/j.bjoms.2009.11.011

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Female rats develop haemolytic anaemia and disseminated thrombosis and infarction in multiple organs, including bone, when exposed to 2-butoxyethanol (BE). There is growing evidence that vascular occlusion of the subchondral bone may play a part in some cases of osteoarthritis. The subchondral bone is the main weight bearer as well as the source of the blood supply to the mandibular articular cartilage. Vascular occlusion is thought to be linked to sclerosis of the subchondral bone associated with disintegration of the articular cartilage. The aim of this study was to find out whether this model of haemolysis and disseminated thrombosis supports the vascular hypothesis of osteoarthritis. Six female rats were given BE orally for 4 consecutive days and the two control rats were given tap water alone. The rats were killed 26 days after the final dose. The mandibular condyles showed histological and radiological features consistent with osteoarthritis in three of the four experimental rats and in neither of the control rats. These results may support the need to explore the vascular mechanism of osteoarthritis further. (C)2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

引用

页码：21 / 25

页数：5

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