Bone: from a reservoir of minerals to a regulator of energy metabolism

被引：81

作者：

Confavreux, Cyrille B. ^{[1
]}

机构：

[1] Univ Lyon, INSERM, U 1033, Hop Edouard Herriot,Hosp Civils Lyon,Dept Rheuma, F-69003 Lyon, France

来源：

KIDNEY INTERNATIONAL | 2011年 / 79卷

关键词：

blood glucose; bone; energy metabolism; fibroblast growth factor-23; leptin; serotonin; osteocalcin; CHRONIC KIDNEY-DISEASE; ATHEROSCLEROTIC CALCIFICATION; MONCKEBERGS SCLEROSIS; LEPTIN REGULATION; BETA-BLOCKERS; MASS; OSTEOCALCIN; EXPRESSION; DENSITY; RISK;

D O I：

10.1038/ki.2011.25

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Besides locomotion, organ protection, and calcium-phosphorus homeostasis, the three classical functions of the skeleton, bone remodeling affects energy metabolism through uncarboxylated osteocalcin, a recently discovered hormone secreted by osteoblasts. This review traces how energy metabolism affects osteoblasts through the central control of bone mass involving leptin, serotoninergic neurons, the hypothalamus, and the sympathetic nervous system. Next, the role of osteocalcin (insulin secretion, insulin sensitivity, and pancreas beta-cell proliferation) in the regulation of energy metabolism is described. Then, the connections between insulin signaling on osteoblasts and the release of uncarboxylated osteocalcin during osteoclast bone resorption through osteoprotegerin are reported. Finally, the understanding of this new bone endocrinology will provide some insights into bone, kidney, and energy metabolism in patients with chronic kidney disease. Kidney International (2011) 79 (Suppl 121), S14-S19; doi:10.1038/ki.2011.25; published online 23 February 2011

引用

收藏

页码：S14 / S19

页数：6

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