Tissue Microarrays in clinical oncology

被引：95

作者：

Voduc, David ^{[1
]}

Kenney, Challayne ^{[2
]}

Nielsen, Torsten O. ^{[3
]}

机构：

[1] British Columbia Canc Agcy, Dept Radiat Oncol, Vancouver, BC V5Z 4E6, Canada

[2] Genet Pathol Evaluat Ctr, Vancouver, BC, Canada

[3] Univ British Columbia, Dept Pathol, Vancouver, BC V5Z 1M9, Canada

来源：

SEMINARS IN RADIATION ONCOLOGY | 2008年 / 18卷 / 02期

关键词：

D O I：

10.1016/j.semradonc.2007.10.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tissue microarray (TMA) is a recently implemented, high-throughput technology for the analysis of molecular markers in oncology. This research tool permits the rapid assessment of a biomarker in thousands of tumor samples, using commonly available laboratory assays such as immunohistochemistry and in situ hybridization. Although introduced less than a decade ago, TMA has proven to be invaluable in the study of tumor biology, the development of diagnostic tests, and the investigation of oncologic biomarkers. This review describes the impact of TMA-based research in clinical oncology and its potential future applications. Technical aspects of TMA construction and the advantages and disadvantages inherent to this technology are also discussed.

引用

页码：89 / 97

页数：9

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