Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex

被引：32

作者：

Chen, Xiaoqiang ^{[1
]}

Wang, Jingyun ^{[2
]}

Sun, Shiguo ^{[1
]}

Fan, Jiangh ^{[1
]}

Wu, Song ^{[2
]}

Liu, Jianfeng ^{[2
]}

Ma, Saijian ^{[2
]}

Zhang, Lizhu ^{[1
]}

Peng, Xiaojun ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

[2] Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116023, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 01期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.bmcl.2007.11.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inspired by the structures of natural nucleases, guanidinium groups were introduced into binuclear iron(III) systems. Compared with the corresponding analogue without guanidinium groups, the new diiron(III) system led to considerable rate enhancement on DNA cleavage. The cooperativity between metal ions and guanidine groups was evidenced by the fact that no significant cleavage was observed after incubating pBR322 plasmid DNA with non-metalated ligands or free Fe3+ ion. DNA binding experiments indicated that introduction of positively charged guanidinium, groups can obtain more than one order of magnitude enhancement in the affinity of complex with DNA. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：109 / 113

页数：5

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