Parkinson's disease patients with bilateral subthalamic deep brain stimulation gain weight

被引：94

作者：

Macia, F

Perlemoine, C

Coman, I

Guehl, D

Burbaud, P

Cuny, E

Gin, H

Rigalleau, V

Tison, F

机构：

[1] Hop Haut Leveque, Serv Neurol, F-33604 Pessac, France

[2] Hop Haut Leveque, Pessac, France

[3] CHU Bordeaux, Hop Pellegrin, Serv Neurochirurg B, Bordeaux, France

来源：

MOVEMENT DISORDERS | 2004年 / 19卷 / 02期

关键词：

Parkinson's disease; deep brain stimulation; subthalamic nucleus; weight gain;

D O I：

10.1002/mds.10630

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Weight, body mass index (BMI) and energy expenditure/energy intake (EE/EI) was studied in 19 Parkinson's disease (PD) patients after subthalamic deep brain stimulation (STN-DBS) versus 14 nonoperated ones. Operated patients had a significant weight gain (WG, + 9.7 +/- 7 kg) and BMI increase (+ 4.7 kg/m(2)). The fat mass was higher after STN-DBS. Resting EE (REE; offdrug/ON stimulation) was significantly decreased in STN-DBS patients, while their daily energy expenditure (DEI) was not significantly different. A significant correlation was found among WG, BMI increase, and pre-operative levodopa-equivalent daily dose, their reduction after STN-DBS, and the differential REE related to stimulation and the REE in the offdrug/OFF stimulation condition. In conclusion, STN-DBS in PD induces a significant WG associated with a reduction in REE without DEI adjustment. (C) 2004 Movement Disorder Society

引用

页码：206 / 212

页数：7

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