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Parkinson's disease patients with bilateral subthalamic deep brain stimulation gain weight

被引：94
作者：
Macia, F
Perlemoine, C
Coman, I
Guehl, D
Burbaud, P
Cuny, E
Gin, H
Rigalleau, V
Tison, F
机构：
[1] Hop Haut Leveque, Serv Neurol, F-33604 Pessac, France
[2] Hop Haut Leveque, Pessac, France
[3] CHU Bordeaux, Hop Pellegrin, Serv Neurochirurg B, Bordeaux, France
来源：
MOVEMENT DISORDERS | 2004年 / 19卷 / 02期
关键词：
Parkinson's disease; deep brain stimulation; subthalamic nucleus; weight gain;
D O I：
10.1002/mds.10630
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Weight, body mass index (BMI) and energy expenditure/energy intake (EE/EI) was studied in 19 Parkinson's disease (PD) patients after subthalamic deep brain stimulation (STN-DBS) versus 14 nonoperated ones. Operated patients had a significant weight gain (WG, + 9.7 +/- 7 kg) and BMI increase (+ 4.7 kg/m(2)). The fat mass was higher after STN-DBS. Resting EE (REE; offdrug/ON stimulation) was significantly decreased in STN-DBS patients, while their daily energy expenditure (DEI) was not significantly different. A significant correlation was found among WG, BMI increase, and pre-operative levodopa-equivalent daily dose, their reduction after STN-DBS, and the differential REE related to stimulation and the REE in the offdrug/OFF stimulation condition. In conclusion, STN-DBS in PD induces a significant WG associated with a reduction in REE without DEI adjustment. (C) 2004 Movement Disorder Society
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页码：206 / 212
页数：7
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