BSKs mediate signal transduction from the receptor kinase BRI1 in Arabidopsis

被引：563

作者：

Tang, Wenqiang ^{[1
]}

Kim, Tae-Wuk ^{[1
]}

Oses-Prieto, Juan A. ^{[2
]}

Sun, Yu ^{[1
]}

Deng, Zhiping ^{[1
]}

Zhu, Shengwei ^{[1
,3
]}

Wang, Ruiju ^{[1
,4
]}

Burlingame, Alma L. ^{[2
]}

Wang, Zhi-Yong ^{[1
]}

机构：

[1] Carnegie Inst Washington, Dept Plant Biol, Stanford, CA 94305 USA

[2] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[3] Chinese Acad Sci, Key Lab Photosynth & Environm Mol Biol, Inst Bot, Beijing 100093, Peoples R China

[4] Nankai Univ, Inst Mol Biol, Coll Life Sci, Tianjin 300071, Peoples R China

来源：

SCIENCE | 2008年 / 321卷 / 5888期

关键词：

D O I：

10.1126/science.1156973

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Brassinosteroids ( BRs) bind to the extracellular domain of the receptor kinase BRI1 to activate a signal transduction cascade that regulates nuclear gene expression and plant development. Many components of the BR signaling pathway have been identified and studied in detail. However, the substrate of BRI1 kinase that transduces the signal to downstream components remains unknown. Proteomic studies of plasma membrane proteins lead to the identification of three homologous BR- signaling kinases ( BSK1, BSK2, and BSK3). The BSKs are phosphorylated by BRI1 in vitro and interact with BRI1 in vivo. Genetic and transgenic studies demonstrate that the BSKs represent a small family of kinases that activate BR signaling downstream of BRI1. These results demonstrate that BSKs are the substrates of BRI1 kinase that activate downstream BR signal transduction.

引用

页码：557 / 560

页数：4

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