Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering

被引：75

作者：

Balog, S. ^{[1
]}

Rodriguez-Lorenzo, L. ^{[1
]}

Monnier, C. A. ^{[1
]}

Obiols-Rabasa, M. ^{[2
]}

Rothen-Rutishauser, B. ^{[1
]}

Schurtenberger, P. ^{[2
]}

Petri-Fink, A. ^{[1
,3
]}

机构：

[1] Univ Fribourg, Adolphe Merkle Inst, CH-1700 Fribourg, Switzerland

[2] Lund Univ, Dept Chem, Phys Chem, S-22100 Lund, Sweden

[3] Univ Fribourg, Dept Chem, CH-1700 Fribourg, Switzerland

来源：

NANOSCALE | 2015年 / 7卷 / 14期

基金：

瑞士国家科学基金会; 瑞典研究理事会;

关键词：

BOVINE SERUM-ALBUMIN; CELL-CULTURE MEDIUM; GOLD NANOPARTICLES; SILICA NANOPARTICLES; PROTEIN INTERACTIONS; COLLOIDAL STABILITY; TIO2; NANOPARTICLES; IRON-OXIDE; IN-VITRO; ENVIRONMENT;

D O I：

10.1039/c4nr06538g

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Light scattering is one of the few techniques available to adequately characterize suspended nanoparticles (NPs) in real time and in situ. However, when it comes to NPs in multicomponent and optically complex aqueous matrices - such as biological media and physiological fluids - light scattering suffers from lack of selectivity, as distinguishing the relevant optical signals from the irrelevant ones is very challenging. We meet this challenge by building on depolarized scattering: Unwanted signals from the matrix are completely suppressed. This approach yields information with an unprecedented signal-to-noise ratio in favour of the NPs and NP-biomolecule corona complexes, which in turn opens the frontier to scattering-based studies addressing the behaviour of NPs in complex physiological/biological fluids.

引用

收藏

页码：5991 / 5997

页数：7

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