Mitogen-activated protein kinase phosphatase: a negative regulator of the mitogen-activated protein kinase cascade

被引：101

作者：

Haneda, M ^{[1
]}

Sugimoto, T ^{[1
]}

Kikkawa, R ^{[1
]}

机构：

[1] Shiga Univ Med Sci, Dept Med 3, Shiga 5202192, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 365卷 / 01期

关键词：

signal transduction; (intracellular); MARK (mitogen-activated protein kinase); dual-specificity phosphatase; MAPK phosphatase;

D O I：

10.1016/S0014-2999(98)00857-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mitogen-activated protein kinases (MAPKs) are activated by various stimuli, such as growth factors, cytokines, or stress, and are considered to be important mediators in intracellular signal transduction networks. The dual-specificity kinases, MAPK kinases (MKKs), which phosphorylate the TXY motif in the catalytic domain of MAPKs, can cause the activation of MAPKs. Recently, a family of dual-specificity phosphatases has been identified, members of which are able to dephosphorylate and inactivate MAPKs. The studies cited in this review have revealed that these MAPK phosphatases might play an important role in various cellular functions by downregulating the MAPK cascade. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 7

页数：7

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