Immune modulation by bacterial outer membrane vesicles

被引：852

作者：

Kaparakis-Liaskos, Maria ^{[1
]}

Ferrero, Richard L. ^{[1
]}

机构：

[1] Monash Univ, Ctr Innate Immun & Infect Dis, MIMR PHI Inst Med Res, Melbourne, Vic 3168, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 06期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

MENINGITIDIS SEROGROUP-B; GRAM-NEGATIVE BACTERIA; NEISSERIA-MENINGITIDIS; HELICOBACTER-PYLORI; PORPHYROMONAS-GINGIVALIS; PSEUDOMONAS-AERUGINOSA; IN-VITRO; HAEMOPHILUS-INFLUENZAE; VACUOLATING CYTOTOXIN; PROTECTIVE IMMUNITY;

D O I：

10.1038/nri3837

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Gram-negative bacteria shed extracellular outer membrane vesicles (OMVs) during their normal growth both in vitro and in vivo. OMVs are spherical, bilayered membrane nanostructures that contain many components found within the parent bacterium. Until recently, OMVs were dismissed as a by-product of bacterial growth; however, findings within the past decade have revealed that both pathogenic and commensal bacteria can use OMVs to manipulate the host immune response. In this Review, we describe the mechanisms through which OMVs induce host pathology or immune tolerance, and we discuss the development of OMVs as innovative nanotechnologies.

引用

页码：375 / 387

页数：13

共 136 条

[1]

Aghasadeghi MR, 2011, CURR HIV RES, V9, P630, DOI 10.2174/157016211798998772

[2]

Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivo [J].

Alaniz, Robert C. ;

Deatherage, Brooke L. ;

Lara, Jimmie C. ;

Cookson, Brad T. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (11) :7692-7701

[3]

Helicobacter pylori Induces MAPK Phosphorylation and AP-1 Activation via a NOD1-Dependent Mechanism [J].

Allison, Cody C. ;

Kufer, Thomas A. ;

Kremmer, Elisabeth ;

Kaparakis, Maria ;

Ferrero, Richard L. .

JOURNAL OF IMMUNOLOGY, 2009, 183 (12) :8099-8109

[4]

A vaccine against serogroup B Neisseria meningitidis: dealing with uncertainty [J].

Andrews, Sophie M. ;

Pollard, Andrew .

LANCET INFECTIOUS DISEASES, 2014, 14 (05) :426-434

[5]

[Anonymous], NATL GEOGR

[6]

Stability of mono- and trivalent meningococcal outer membrane vesicle vaccines [J].

Arigita, C ;

Jiskoot, W ;

Westdijk, J ;

van Ingen, C ;

Hennink, WE ;

Crommelin, DJA ;

Kersten, GFA .

VACCINE, 2004, 22 (5-6) :629-642

[7]

Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate [J].

Asensio, Cristian J. A. ;

Emilia Gaillard, Maria ;

Moreno, Griselda ;

Bottero, Daniela ;

Zurita, Eugenia ;

Rumbo, Martin ;

van der Ley, Peter ;

van der Ark, Arno ;

Hozbor, Daniela .

VACCINE, 2011, 29 (08) :1649-1656

[8]

Microbial biosynthesis of designer outer membrane vesicles [J].

Baker, Jenny L. ;

Chen, Linxiao ;

Rosentha, Joseph A. ;

Putnam, David ;

DeLisa, Matthew P. .

CURRENT OPINION IN BIOTECHNOLOGY, 2014, 29 :76-84

[9]

The Helicobacter pylori Virulence Effector CagA Abrogates Human β-Defensin 3 Expression via Inactivation of EGFR Signaling [J].

Bauer, Bianca ;

Pang, Ervinna ;

Holland, Carsten ;

Kessler, Mirjana ;

Bartfeld, Sina ;

Meyer, Thomas F. .

CELL HOST & MICROBE, 2012, 11 (06) :576-586

[10]

Purification of outer membrane vesicles from Pseudomonas aeruginosa and their activation of an IL-8 response [J].

Bauman, Susanne J. ;

Kuehn, Meta J. .

MICROBES AND INFECTION, 2006, 8 (9-10) :2400-2408

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