Increased interleukin-4 and interleukin-5 production in response to Schistosoma haematobium adult worm antigens correlates with lack of reinfection after treatment
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Medhat, A
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机构:Case Western Reserve Univ, Sch Med, Dept Med, Div Geog Med, Cleveland, OH 44106 USA
Medhat, A
Shehata, M
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机构:Case Western Reserve Univ, Sch Med, Dept Med, Div Geog Med, Cleveland, OH 44106 USA
Shehata, M
Bucci, K
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机构:Case Western Reserve Univ, Sch Med, Dept Med, Div Geog Med, Cleveland, OH 44106 USA
Bucci, K
Mohamed, S
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机构:Case Western Reserve Univ, Sch Med, Dept Med, Div Geog Med, Cleveland, OH 44106 USA
Mohamed, S
Dief, ADE
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机构:Case Western Reserve Univ, Sch Med, Dept Med, Div Geog Med, Cleveland, OH 44106 USA
Dief, ADE
Badary, S
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机构:Case Western Reserve Univ, Sch Med, Dept Med, Div Geog Med, Cleveland, OH 44106 USA
Badary, S
Galal, H
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机构:Case Western Reserve Univ, Sch Med, Dept Med, Div Geog Med, Cleveland, OH 44106 USA
Galal, H
Nafeh, M
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机构:Case Western Reserve Univ, Sch Med, Dept Med, Div Geog Med, Cleveland, OH 44106 USA
Nafeh, M
King, CL
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机构:Case Western Reserve Univ, Sch Med, Dept Med, Div Geog Med, Cleveland, OH 44106 USA
King, CL
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[1] Case Western Reserve Univ, Sch Med, Dept Med, Div Geog Med, Cleveland, OH 44106 USA
Acquired immunity to human schistosomiasis correlates with increased serum levels of schistosome antigen-specific IgE. Since interleukin (IL)-4 stimulates IgE production, the hypothesis that Th2-associated cell-mediated immunity participates in protection to reinfection was studied in a cohort of adolescent boys 12-18 months after chemotherapeutic cure in Upper Egypt. Initial Schistosoma haematobium prevalence was 51% and posttreatment incidence was 44%. Water contact was similar between putatively resistant and susceptible patients. Resistant persons had a 3.5- to 14-fold greater frequency of schistosome adult worm antigen (SWAP)-specific lymphocytes secreting IL-5 or IL-4 (by ELISPOT) and IL-5 or IL-4 production in peripheral blood lymphocyte culture supernatants (P < .05 to < .001, n = 48) versus susceptible subjects (n = 38). In contrast, SWAP-induced interferon-gamma and IL-10 production and lymphocyte proliferation were similar between the 2 groups. Schistosome egg antigen and streptolysin O each stimulated similar cytokine production in susceptible and resistant persons. Thus, enhanced SWAP-driven IL-4 and IL-5 production correlates with immunity to reinfection in adolescents exposed to urinary schistosomiasis.