Increased interleukin-4 and interleukin-5 production in response to Schistosoma haematobium adult worm antigens correlates with lack of reinfection after treatment

被引:61
作者
Medhat, A
Shehata, M
Bucci, K
Mohamed, S
Dief, ADE
Badary, S
Galal, H
Nafeh, M
King, CL
机构
[1] Case Western Reserve Univ, Sch Med, Dept Med, Div Geog Med, Cleveland, OH 44106 USA
[2] Assiut Univ, Dept Trop Med, Assiut, Egypt
关键词
D O I
10.1086/515630
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Acquired immunity to human schistosomiasis correlates with increased serum levels of schistosome antigen-specific IgE. Since interleukin (IL)-4 stimulates IgE production, the hypothesis that Th2-associated cell-mediated immunity participates in protection to reinfection was studied in a cohort of adolescent boys 12-18 months after chemotherapeutic cure in Upper Egypt. Initial Schistosoma haematobium prevalence was 51% and posttreatment incidence was 44%. Water contact was similar between putatively resistant and susceptible patients. Resistant persons had a 3.5- to 14-fold greater frequency of schistosome adult worm antigen (SWAP)-specific lymphocytes secreting IL-5 or IL-4 (by ELISPOT) and IL-5 or IL-4 production in peripheral blood lymphocyte culture supernatants (P < .05 to < .001, n = 48) versus susceptible subjects (n = 38). In contrast, SWAP-induced interferon-gamma and IL-10 production and lymphocyte proliferation were similar between the 2 groups. Schistosome egg antigen and streptolysin O each stimulated similar cytokine production in susceptible and resistant persons. Thus, enhanced SWAP-driven IL-4 and IL-5 production correlates with immunity to reinfection in adolescents exposed to urinary schistosomiasis.
引用
收藏
页码:512 / 519
页数:8
相关论文
共 47 条
[11]   SCHISTOSOMA-SPECIFIC HELPER T-CELL CLONES FROM SUBJECTS RESISTANT TO INFECTION BY SCHISTOSOMA-MANSONI ARE TH0/2 [J].
COUISSINIERPARIS, P ;
DESSEIN, AJ .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (08) :2295-2302
[12]   IDENTIFICATION OF A MAJOR T-CELL IMMUNOGEN IN THE ANTI-SCHISTOSOME RESPONSE OF ADULT RESIDENTS IN AN AREA ENDEMIC FOR SCHISTOSOMA-MANSONI [J].
COUISSINIERPARIS, P ;
BOURGOIS, A ;
DESSEIN, H ;
BACELLAR, O ;
RODRIGUES, V ;
KOHLSTADT, S ;
BUONAVISTA, N ;
PENE, J ;
DESSEIN, AJ .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (04) :903-910
[13]   CORRELATION BETWEEN CELL-MEDIATED-IMMUNITY AND DEGREE OF INFECTION IN SUBJECTS LIVING IN AN ENDEMIC AREA OF SCHISTOSOMIASIS [J].
DEJESUS, AMR ;
ALMEIDA, RP ;
BACELLAR, O ;
ARAUJO, MI ;
DEMEURE, C ;
BINA, JC ;
DESSEIN, AJ ;
CARVALHO, EM .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (01) :152-158
[14]   EVIDENCE FOR ENHANCEMENT OF IGG1 SUBCLASS EXPRESSION IN MICE POLYVACCINATED WITH RADIATION-ATTENUATED CERCARIAE OF SCHISTOSOMA-MANSONI AND THE ROLE OF THIS ISOTYPE IN SERUM-TRANSFERRED IMMUNITY [J].
DELGADO, V ;
MCLAREN, DJ .
PARASITE IMMUNOLOGY, 1990, 12 (01) :15-32
[15]   RESISTANCE TO SCHISTOSOMA-MANSONI IN HUMANS - INFLUENCE OF THE IGE/IGG4 BALANCE AND IGG2 IN IMMUNITY TO REINFECTION AFTER CHEMOTHERAPY [J].
DEMEURE, CE ;
RIHET, P ;
ABEL, L ;
OUATTARA, M ;
BOURGOIS, A ;
DESSEIN, AJ .
JOURNAL OF INFECTIOUS DISEASES, 1993, 168 (04) :1000-1008
[16]  
DESSEIN AJ, 1988, J IMMUNOL, V140, P2727
[17]   IMMUNITY AFTER TREATMENT OF HUMAN SCHISTOSOMIASIS - ASSOCIATION BETWEEN IGE ANTIBODIES TO ADULT WORM ANTIGENS AND RESISTANCE TO REINFECTION [J].
DUNNE, DW ;
BUTTERWORTH, AE ;
FULFORD, AJC ;
KARIUKI, HC ;
LANGLEY, JG ;
OUMA, JH ;
CAPRON, A ;
PIERCE, RJ ;
STURROCK, RF .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (06) :1483-1494
[18]   HUMAN-ANTIBODY RESPONSES TO SCHISTOSOMA-MANSONI - THE INFLUENCE OF EPITOPES SHARED BETWEEN DIFFERENT LIFE-CYCLE STAGES ON THE RESPONSE TO THE SCHISTOSOMULUM [J].
DUNNE, DW ;
GRABOWSKA, AM ;
FULFORD, AJC ;
BUTTERWORTH, AE ;
STURROCK, RF ;
KOECH, D ;
OUMA, JH .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (01) :123-131
[19]   Cytokine regulation of host defense against parasitic gastrointestinal nematodes: Lessons from studies with rodent models [J].
Finkelman, FD ;
SheaDonohue, T ;
Goldhill, J ;
Sullivan, CA ;
Morris, SC ;
Madden, KB ;
Gause, WC ;
Urban, JF .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :505-533
[20]   Water contact observations in Kenyan communities endemic for schistosomiasis: Methodology and patterns of behaviour [J].
Fulford, AJC ;
Ouma, JH ;
Kariuki, HC ;
Thiongo, FW ;
Klumpp, R ;
Kloos, H ;
Sturrock, RF ;
Butterworth, AE .
PARASITOLOGY, 1996, 113 :223-241