Developing new metal-based therapeutics: challenges and opportunities

被引：289

作者：

Hambley, Trevor W. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Ctr Heavy Met Res, Sydney, NSW 2006, Australia

来源：

DALTON TRANSACTIONS | 2007年 / 43期

关键词：

D O I：

10.1039/b706075k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Unexpected side effects and problems experienced in clinical trials have created a difficult environment for those developing new pharmaceuticals and, as a consequence, the number of new chemical entities being registered has fallen to a historic low. Those developing metal-based therapeutics will face the same difficulties, but this environment also provides many opportunities for creative solutions to be applied to overcoming the problems and concerns. In this perspective, these challenges and opportunities are considered in the context of examples of a number of classes of metal-based therapeutics.

引用

页码：4929 / 4937

页数：9

共 96 条

[1]

ALDERDEN RA, 2007, IN PRESS J AM CHEM S

[2]

ALDERDEN RA, 2006, THESIS U SYNDNEY

[3]

Alessio E, 2004, MET IONS BIOL SYST, V42, P323

[4]

Anderson RF, 1996, BRIT J CANCER, V74, pS48

[5] Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance [J].

Ang, WH ;

Khalaila, I ;

Allardyce, CS ;

Juillerat-Jeanneret, L ;

Dyson, PJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (05) :1382-1383

[6] Organometallic compounds with biological activity: A very selective and highly potent cellular inhibitor for glycogen synthase kinase 3 [J].

Atilla-Gokcumen, G. Ekin ;

Williams, Douglas S. ;

Bregman, Howard ;

Pagano, Nicholas ;

Meggers, Eric .

CHEMBIOCHEM, 2006, 7 (09) :1443-1450

[7] Synthesis, characterization, and cytotoxicity of a series of estrogen-tethered platinum(IV) complexes [J].

Barnes, KR ;

Kutikov, A ;

Lippard, SJ .

CHEMISTRY & BIOLOGY, 2004, 11 (04) :557-564

[8] Boron neutron capture therapy of cancer: Current status and future prospects [J].

Barth, RF ;

Coderre, JA ;

Vicente, MGH ;

Blue, TE .

CLINICAL CANCER RESEARCH, 2005, 11 (11) :3987-4002

[9] Light-activated destruction of cancer cell nuclei by platinum diazide complexes [J].

Bednarski, PJ ;

Grünert, R ;

Zielzki, M ;

Wellner, A ;

Mackay, FS ;

Sadler, PJ .

CHEMISTRY & BIOLOGY, 2006, 13 (01) :61-67

[10] Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma [J].

Billecke, Christine ;

Finniss, Susan ;

Tahash, Laura ;

Miller, Cathie ;

Mikkelsen, Tom ;

Farrell, Nicholas P. ;

Boegler, Oliver .

NEURO-ONCOLOGY, 2006, 8 (03) :215-226

← 1 2 3 4 5 6 7 8 9 10 →