Growth, telomere dynamics and successful and unsuccessful human aging

被引：42

作者：

Aviv, A

Levy, D

Mangel, M

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Cardiovasc Res Inst, Hypertens Res Ctr, Newark, NJ 07103 USA

[2] NHLBI, Framingham, MA USA

[3] Framingham Heart Dis Epidemiol Study, Framingham, MA USA

[4] Univ Calif Santa Cruz, Jack Baskin Sch Engn, Dept Appl Math & Stat, Santa Cruz, CA 95064 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2003年 / 124卷 / 07期

关键词：

telomeres; aging; growth; somatic cells; replication;

D O I：

10.1016/S0047-6374(03)00143-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This paper links mass trajectories with telomere dynamics to construct theoretical models of successful and unsuccessful aging in human beings. It couples parameters of telomere length in somatic cells, as expressed by the terminal restriction fragment (TRF), at birth and the rate of telomere attrition thereafter with nonlinear models of somatic growth to predict the probability of surviving disease free, based on the assumption that telomere length in replicating somatic cells is a surrogate indicator of aging determinants in humans. The models capture aspects of individual variation in successful and unsuccessful aging and the long-term consequences of rapid growth early in life. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：829 / 837

页数：9

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