Derivation of genetic interaction networks from quantitative phenotype data

被引：86

作者：

Drees, BL ^{[1
]}

Thorsson, V ^{[1
]}

Carter, GW ^{[1
]}

Rives, AW ^{[1
]}

Raymond, MZ ^{[1
]}

Avila-Campillo, I ^{[1
]}

Shannon, P ^{[1
]}

Galitski, T ^{[1
]}

机构：

[1] Inst Syst Biol, Seattle, WA 98103 USA

来源：

GENOME BIOLOGY | 2005年 / 6卷 / 04期

关键词：

D O I：

10.1186/gb-2005-6-4-r38

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have generalized the derivation of genetic-interaction networks from quantitative phenotype data. Familiar and unfamiliar modes of genetic interaction were identified and defined. A network was derived from agar-invasion phenotypes of mutant yeast. Mutations showed specific modes of genetic interaction with specific biological processes. Mutations formed cliques of significant mutual information in their large-scale patterns of genetic interaction. These local and global interaction patterns reflect the effects of gene perturbations on biological processes and pathways.

引用

页数：10

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