A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

被引：94

作者：

Browne, Duncan L. ^{[1
]}

Baumann, Marcus ^{[1
]}

Harji, Bashir H. ^{[2
]}

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

[2] Cambridge Reactor Design, Brookfield Business Ctr, Unit D2, Cottenham CB24 8PS, England

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 13期

基金：

英国工程与自然科学研究理事会;

关键词：

MICROREACTOR SYSTEM; MULTISTEP SYNTHESIS; REACTORS; SPACE;

D O I：

10.1021/ol2010006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new machine for conducting continuous flow processes at low temperatures on a laboratory scale is reported. The use of this cryogenic flow reactor has been demonstrated by the preparation of a variety of (hetero)aromatic boronic acids and esters via lithium halogen exchange chemistry. Furthermore, scale-up of the reaction conditions not only demonstrates the application of this device for the preparation of useful building blocks but also combines the ability to process n-butyllithium directly through pump heads attached to the unit.

引用

页码：3312 / 3315

页数：4

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