Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

被引：199

作者：

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

Mansfield, Andrew C. ^{[2
]}

Smith, Christopher D. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, ITC, Cambridge CB2 1EW, England

[2] Pfizer Global R&D Res Ctr, Sandwich CT13 9NJ, Kent, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 22期

关键词：

alkynes; azides; flow reactors; multistep syntheses; supported reagents; SOLID-SUPPORTED REAGENTS; ORGANIC-SYNTHESIS; HIGH-PRESSURE; IMMOBILIZED REAGENTS; CARBONYL-COMPOUNDS; CONCISE SYNTHESIS; PERRUTHENATE PSP; SWERN OXIDATION; BOND FORMATION; MICROREACTOR;

D O I：

10.1002/anie.200900970

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multistep in flow: The Seyferth-Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three-step oxidation/homologation/copper(I)-catalyzed azide-alkyne cycloaddition sequence without isolation of intermediates (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4017 / 4021

页数：5

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