Microreactor technology:: Continuous synthesis of 1H-isochromeno[3,4-d]imidazol-5-ones

被引：9

作者：

Acke, Davy R. J. ^{[1
]}

Stevens, Christian V. ^{[1
]}

Roman, Bart I. ^{[1
]}

机构：

[1] Univ Ghent, Fac Biosci Engn, Dept Organ Chem, Res Grp SynBioC, B-9000 Ghent, Belgium

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2008年 / 12卷 / 05期

关键词：

D O I：

10.1021/op700289e

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A synthetic method was evaluated to form 1H-isochromeno[3,4-d]imidazol-5-ones via ring closure starting from 3-amino-4-(aryl-amino)-1H-isochromen-1-ones. The method was implemented and optimized in a microreactor environment. It was possible to synthesize these compounds in a continuous mode with an output up to 2.2 g/h.

引用

页码：921 / 928

页数：8

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