MicroRNAs and viral infection

被引：210

作者：

Sullivan, CS ^{[1
]}

Ganem, D ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Med, George Williams Hooper Fdn, Howard Hughes Med Inst, San Francisco, CA 94143 USA

来源：

MOLECULAR CELL | 2005年 / 20卷 / 01期

关键词：

D O I：

10.1016/j.molcel.2005.09.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) play a pivotal role in the regulation of genes involved in diverse processes such as development, differentiation, and cellular growth control. Recently, many viral-encoded miRNAs have been discovered, for the most part in viruses transcribed from double-stranded DNA genomes. As with their cellular counterparts, the functions of most viral-derived miRNAs are unknown; however, functions have been documented or proposed for viral miRNAs from three different viral families-herpesviruses, polyomaviruses, and retroviruses. Several virus-encoded miRNAs have unique aspects to their biogenesis, such as the polymerase that transcribes them or their location within the precursor transcript. Additionally, viral interactions with cellular miRNAs have also been identified, and these have substantially expanded our appreciation of miRNA functions.

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收藏

页码：3 / 7

页数：5

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