MicroRNA biogenesis: Coordinated cropping and dicing

被引：1912

作者：

Kim, VN ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Biol Sci, Seoul 151742, South Korea

[2] Seoul Natl Univ, Inst Mol Biol & Genet, Seoul 151742, South Korea

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 05期

关键词：

D O I：

10.1038/nrm1644

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The recent discovery of microRNAs (miRNAs) took many by surprise because of their unorthodox features and widespread functions. These tiny, similar to 22-nucleotide, RNAs control several pathways including developmental timing, haematopoiesis, organogenesis, apoptosis, cell proliferation and possibly even tumorigenesis. Among the most pressing questions regarding this unusual class of regulatory miRNA-encoding genes is how miRNAs are produced in cells and how the genes themselves are controlled by various regulatory networks.

引用

页码：376 / 385

页数：10

共 128 条

[1] A uniform system for microRNA annotation [J].

Ambros, V ;

Bartel, B ;

Bartel, DP ;

Burge, CB ;

Carrington, JC ;

Chen, XM ;

Dreyfuss, G ;

Eddy, SR ;

Griffiths-Jones, S ;

Marshall, M ;

Matzke, M ;

Ruvkun, G ;

Tuschl, T .

RNA, 2003, 9 (03) :277-279

[2] MicroRNAs and other tiny endogenous RNAs in C-elegans [J].

Ambros, V ;

Lee, RC ;

Lavanway, A ;

Williams, PT ;

Jewell, D .

CURRENT BIOLOGY, 2003, 13 (10) :807-818

[3] The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[4] The small RNA profile during Drosophila melanogaster development [J].

Aravin, AA ;

Lagos-Quintana, M ;

Yalcin, A ;

Zavolan, M ;

Marks, D ;

Snyder, B ;

Gaasterland, T ;

Meyer, J ;

Tuschl, T .

DEVELOPMENTAL CELL, 2003, 5 (02) :337-350

[5] Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D-melanogaster germline [J].

Aravin, AA ;

Naumova, NM ;

Tulin, AV ;

Vagin, VV ;

Rozovsky, YM ;

Gvozdev, VA .

CURRENT BIOLOGY, 2001, 11 (13) :1017-1027

[6] Dissection of a natural RNA silencing process in the Drosophila melanogaster germ line [J].

Aravin, AA ;

Klenov, MS ;

Vagin, VV ;

Bantignies, F ;

Cavalli, G ;

Gvozdev, VA .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (15) :6742-6750

[7] Regulation of flowering time and floral organ identity by a microRNA and its APETALA2-like target genes [J].

Aukerman, MJ ;

Sakai, H .

PLANT CELL, 2003, 15 (11) :2730-2741

[8] Probing microRNAs with microarrays: Tissue specificity and functional inference [J].

Babak, T ;

Zhang, W ;

Morris, Q ;

Blencowe, BJ ;

Hughes, TR .

RNA, 2004, 10 (11) :1813-1819

[9] MicroRNA expression detected by oligonucleotide microarrays: System establishment and expression profiling in human tissues [J].

Barad, O ;

Meiri, E ;

Avniel, A ;

Aharonov, R ;

Barzilai, A ;

Bentwich, I ;

Einav, U ;

Glad, S ;

Hurban, P ;

Karov, Y ;

Lobenhofer, EK ;

Sharon, E ;

Shiboleth, YM ;

Shtutman, M ;

Bentwich, Z ;

Einat, P .

GENOME RESEARCH, 2004, 14 (12) :2486-2494

[10] Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs [J].

Bartel, DP ;

Chen, CZ .

NATURE REVIEWS GENETICS, 2004, 5 (05) :396-400

← 1 2 3 4 5 6 7 8 9 10 →