Functions of granulocyte-macrophage colony-stimulating factor

被引:171
作者
Fleetwood, AJ
Cook, AD
Hamilton, JA [1 ]
机构
[1] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Arthrit & Inflammat Res Ctr, Parkville, Vic 3010, Australia
[2] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Cooperat Res Ctr Chron Inflammatory Dis, Parkville, Vic 3010, Australia
关键词
inflammation; macrophages; granulocytes; dendritic cells;
D O I
10.1615/CritRevImmunol.v25.i5.50
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
GM-CSF was originally defined by its ability to generate in vitro granulocyte and macrophage colonies from bone marrow precursor cells. Apart from its physiological role in the control of alveolar macrophage development, it now appears more likely that its major role lies in its ability to govern the properties of the more mature myeloid cells of the granulocyte and macrophage lineages, particularly during host defence and inflammatory reactions. Recent evidence is summarized below for a key role for GM-CSF in inflammatory and autoimmune diseases, making it therefore worthy of consideration for targeting. Such evidence includes disease exacerbation following its administration and amelioration of disease in animal models by GM-CSF gene targeting or by anti-GM-CSF antibody blockade. This review summarizes the evidence supporting a major role for GM-CSF in inflammation and autoimmunity and its functions as major regulator governing granulocyte and macrophage lineage populations at all stages of maturation.
引用
收藏
页码:405 / 428
页数:24
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