Chemoselective modification of proteins: hitting the target

被引：97

作者：

Carrico, Isaac S. ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11790 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2008年 / 37卷 / 07期

关键词：

D O I：

10.1039/b703364h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of synthetic molecules to modulate and track biological events is a central component of chemical biology. As a result, the precise, covalent modi. cation of biomolecules is a key goal for this field. Several strategies have emerged that allow specific tailoring of polypeptides through either endogenous residues or introduced functionality. This tutorial review discusses these recent advances in the context of in vitro and in vivo applications.

引用

页码：1423 / 1431

页数：9

共 46 条

[1] New biarsenical Ligands and tetracysteine motifs for protein labeling in vitro and in vivo: Synthesis and biological applications [J].

Adams, SR ;

Campbell, RE ;

Gross, LA ;

Martin, BR ;

Walkup, GK ;

Yao, Y ;

Llopis, J ;

Tsien, RY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (21) :6063-6076

[2] A comparative study of bioorthogonal reactions with azides [J].

Agard, Nicholas J. ;

Baskin, Jeremy M. ;

Prescher, Jennifer A. ;

Lo, Anderson ;

Bertozzi, Carolyn R. .

ACS CHEMICAL BIOLOGY, 2006, 1 (10) :644-648

[3] A strain-promoted [3+2] azide-alkyne cycloaddition for covalent modification of blomolecules in living systems [J].

Agard, NJ ;

Prescher, JA ;

Bertozzi, CR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (46) :15046-15047

[4] Kinetically controlled ligation for the convergent chemical synthesis of proteins [J].

Bang, Duhee ;

Pentelute, Brad L. ;

Kent, Stephen B. H. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (24) :3985-3988

[5] Copper-free click chemistry for dynamic in vivo imaging [J].

Baskin, Jeremy M. ;

Prescher, Jennifer A. ;

Laughlin, Scott T. ;

Agard, Nicholas J. ;

Chang, Pamela V. ;

Miller, Isaac A. ;

Lo, Anderson ;

Codelli, Julian A. ;

Bertozzi, Carolyn R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (43) :16793-16797

[6] Fluorescence visualization of newly synthesized proteins in mammalian cells [J].

Beatty, Kimberly E. ;

Liu, Julie C. ;

Xie, Fang ;

Dieterich, Daniela C. ;

Schuman, Erin M. ;

Wang, Qian ;

Tirrell, David A. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (44) :7364-7367

[7] Introducing genetically encoded aldehydes into proteins [J].

Carrico, Isaac S. ;

Carlson, Brian L. ;

Bertozzi, Carolyn R. .

NATURE CHEMICAL BIOLOGY, 2007, 3 (06) :321-322

[8] Site-specific labeling of proteins with small molecules in live cells [J].

Chen, I ;

Ting, AY .

CURRENT OPINION IN BIOTECHNOLOGY, 2005, 16 (01) :35-40

[9] Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase [J].

Chen, I ;

Howarth, M ;

Lin, WY ;

Ting, AY .

NATURE METHODS, 2005, 2 (02) :99-104

[10] Non-canonical amino acids in protein polymer design [J].

Connor, Rebecca E. ;

Tirrell, David A. .

POLYMER REVIEWS, 2007, 47 (01) :9-28

← 1 2 3 4 5 →