Kinetically controlled ligation for the convergent chemical synthesis of proteins

被引：221

作者：

Bang, Duhee ^{[1
]}

Pentelute, Brad L. ^{[1
]}

Kent, Stephen B. H. ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Inst Biophys Dynam, Ctr Integrat Sci, Chicago, IL 60637 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 24期

关键词：

kinetics; native chemical ligation; peptides; protein synthesis;

D O I：

10.1002/anie.200600702

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Converging on the goal: New chemistry enables the key Cys-peptide-(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3985 / 3988

页数：4

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