Modification of plant N-glycans processing: The future of producing therapeutic protein by transgenic plants

被引：29

作者：

Chen, M ^{[1
]}

Liu, XW ^{[1
]}

Wang, ZK ^{[1
]}

Song, J ^{[1
]}

Qi, QS ^{[1
]}

Wang, PG ^{[1
]}

机构：

[1] Shandong Univ, Sch Life Sci, State Key Lab Microbial Technol, Jinan 250100, Peoples R China

来源：

MEDICINAL RESEARCH REVIEWS | 2005年 / 25卷 / 03期

关键词：

therapeutic protein; transgenic plants; glycosylation;

D O I：

10.1002/med.20022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Transgenic plants are regarded as one of the most promising systems for the production of human therapeutic proteins. The number of therapeutic proteins successfully produced in plants is steadily arising. However, the glycoproteins normally produced from plants are not the same as native therapeutic proteins produced from mammals or humans. In addition to in vitro enzymatic modeling glycoproteins, there are two gene manipulation strategies to humanize plant N-glycans connected to the glycoproteins. One is retaining the recombinant glycoproteins in endoplasmic reticulum (ER), the site where few specific modifications of N-glycans occurs. The other is inhibiting the plant endogenous Golgi glycosyltransferase and/or adding new glycosyltransferase from mammalians. In this review, the biosynthesis of N-glycans in plants, the modification of the plant N-glycans processing will be discussed. (c) 2004 Wiley Periodicals, Inc.

引用

页码：343 / 360

页数：18

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