Infrared and Raman spectra of a single resin bead for analysis of solid-phase reactions and use in encoding combinatorial libraries

被引：32

作者：

Rahman, SS

Busby, DJ

Lee, DC

机构：

[1] SmithKline Beecham Pharmaceut, Dept Med Chem, Harlow CM19 5AW, Essex, England

[2] SmithKline Beecham Pharmaceut, Dept Analyt Sci, Harlow CM19 5AW, Essex, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 18期

关键词：

D O I：

10.1021/jo980258w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of lysine amides 2 to 7 tagged with different combinations of either Raman- and/or infrared (IR)-active groups (4-cyanobenzoyl chloride, 3,5-di-tert-butyl-4-hydroxybenzoic acid, or 4-pentynoic acid) have been synthesized on Sasrin resin. Randomly selected beads of unknown identity were then analyzed by Fourier transform infrared (FTIR) and Raman microspectrometry. Using; a combination of these two spectroscopic techniques, the six amide derivatives 2 to 7 and the unfunctionalized lysine template 1 were unambiguously identified from their Raman and FTIR spectra. The potential applications of FTIR and Raman microspectrometry for analysis of organic reactions on solid support and for encoding combinatorial libraries has been demonstrated.

引用

页码：6196 / 6199

页数：4

共 13 条

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