Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development

被引:189
作者
Chauvet, Sophie [1 ]
Cohen, Sarnia [1 ]
Yoshida, Yutaka [2 ,3 ,7 ]
Fekrane, Lylia [1 ]
Livet, Jean [8 ]
Gayet, Odile [9 ]
Segu, Louis [10 ]
Buhot, Marie-Christine [10 ]
Jessell, Thomas M. [2 ,3 ,7 ]
Henderson, Christopher E. [4 ,5 ,6 ,7 ]
Mann, Fanny [1 ]
机构
[1] UnivMediterranee, Dev Biol Inst Marseille Luminy, CNRS, UMR 6216, F-13288 Marseille 09, France
[2] Columbia Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA
[3] Columbia Univ, Howard Hughes Med Inst, Dept Neurosci, New York, NY 10032 USA
[4] Columbia Univ, Dept Pathol, New York, NY 10032 USA
[5] Columbia Univ, Dept Neurol, New York, NY 10032 USA
[6] Columbia Univ, Dept Neurosci, New York, NY 10032 USA
[7] Columbia Univ, Ctr Motor Neuron Biol & Dis, New York, NY 10032 USA
[8] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
[9] INSERM, U624, F-13288 Marseille 09, France
[10] CNRS, UMR 5106, Cognit Neurosci Lab, F-33405 Talence, France
基金
英国惠康基金;
关键词
D O I
10.1016/j.neuron.2007.10.019
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The establishment of functional neural circuits requires the guidance of axons in response to the actions of secreted and cell-surface molecules such as the semaphorins. Semaphorin 3E and its receptor PlexinD1 are expressed in the brain, but their functions are unknown. Here, we show that Sema3E/PlexinD1 signaling plays an important role in initial development of descending axon tracts in the forebrain. Early errors in axonal projections are reflected in behavioral deficits in Sema3E null mutant mice. Two distinct signaling mechanisms can be distinguished downstream of Sema3E. On cortico-fugal and striatonigral neurons expressing PlexinD1 but not Neuropilin-1, Sema3E acts as a repellent. In contrast, on subiculo-mammillary neurons coexpressing PlexinD1 and Neuropilin-1, Sema3E acts as an attractant. The extracellular domain of Neuropilin-1 is sufficient to convert repulsive signaling by PlexinD1 to attraction. Our data therefore reveal a "gating" function of neuropilins in semaphorin-plexin signaling during the assembly of forebrain neuronal circuits.
引用
收藏
页码:807 / 822
页数:16
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