Mixed organofluorine-organosilicon chemistry. 8. One-pot synthesis of 2,2-difluoro-1,5 diketones from acylsilanes, trifluoromethyltrimethylsilane and enones, and their annulation reaction

被引：67

作者：

Lefebvre, O ^{[1
]}

Brigaud, T ^{[1
]}

Portella, C ^{[1
]}

机构：

[1] Univ Reims, Fac Sci, Lab React Select & Applicat, CNRS UMR 6519, F-51687 Reims 2, France

来源：

TETRAHEDRON | 1998年 / 54卷 / 22期

关键词：

D O I：

10.1016/S0040-4020(98)00224-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the synthesis of 2,2-difluoro-1,5-diketones in a one-pot procedure from an acylsilane and trifluoromethyltrimethylsilane, via reaction of difluoroenoxysilanes and enones under electrophilic activation. These diketones are interesting building blocks for the synthesis of gem-difluoro enones or substituted fluorophenols, depending on the annulation conditions. The annulation proceeds with complete regioselectivity controlled by the fluorine substitution. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5939 / 5948

页数：10

共 18 条

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