Karyotype variability in Trypanosoma cruzi

被引：58

作者：

Henriksson, J

Aslund, L

Pettersson, U

机构：

[1] Department of Medical Genetics, Biomedical Center, Uppsala University

来源：

PARASITOLOGY TODAY | 1996年 / 12卷 / 03期

关键词：

D O I：

10.1016/0169-4758(96)80670-3

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Like many other protozoan parasites, Trypanosoma cruzi (the causative agent of Chagas disease) has a plastic genome. Chromosome size polymorphisms occur in different strains of T. cruzi as well as among clones originating from the same strain. Despite this polymorphism, major interchromosomal rearrangements appear to be rare since several linkage groups of chromosomal markers are well conserved among different T. cruzi strains. In addition, some correlation has been found between karyotype variability and classification by multilocus enzyme electrophoresis. In this review, Jan Henriksson, Lena Aslund and Ulf Pettersson discuss the genomic variability and suggest that amplification of repetitive sequences or members of gene families make a major contribution to the chromosomal size variation.

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收藏

页码：108 / 114

页数：7

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