Extensive white-matter changes in case of adult polyglucosan body disease

被引：22

作者：

Berkhoff, M

Weis, J

Schroth, G

Sturzenegger, M

机构：

[1] Inselspital Bern, Dept Neurol, CH-3010 Bern, Switzerland

[2] Univ Bern, Dept Neuroradiol, CH-3010 Bern, Switzerland

[3] Univ Bern, Dept Neuropathol, CH-3010 Bern, Switzerland

来源：

NEURORADIOLOGY | 2001年 / 43卷 / 03期

关键词：

adult polyglucosan body disease; magnetic resonance imaging; white matter;

D O I：

10.1007/s002340000425

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Extensive white matter signal changes were observed on T2-weighted images of a 49-year-old man. He presented with a slowly progressive gait disorder, and finally developed severe dementia. Extensive metabolic and infectious investigations failed to disclose the underlying cause during life, Autopsy revealed adult polyglucosan body disease. We discuss MRI findings likely to permit this diagnosis if combined with clinical findings and nerve or skin biopsy.

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页码：234 / 236

页数：3

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