Synthesis and LC characterization of clenbuterol molecularly imprinted polymers

被引：24

作者：

Masci, G ^{[1
]}

Casati, G ^{[1
]}

Crescenzi, V ^{[1
]}

机构：

[1] Univ Rome La Sapienza, Dept Chem, I-00185 Rome, Italy

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2001年 / 25卷 / 02期

关键词：

molecularly imprinted polymers; clenbuterol; adrenergic drugs; hydrophobic interactions;

D O I：

10.1016/S0731-7085(00)00477-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Highly selective non-covalent clenbuterol (CL) imprinted polymers were prepared using methacrylic acid as monomer and ethylene glycol dimethacrylale as cross-linking agent. HPLC experiments with columns packed with this material showed that CL are selectively recognised with respect to all other adrenergic substances studied using a phosphate buffer/acetonitrile eluent. The separation was strongly dependent on pH and the organic/aqueous phase ratio. An important contribution to the recognition mechanism from hydrophobic interactions was found at higher water content. These results demonstrate that a novel family of absorbents with high selectivity for CL was obtained which can be exploited in solid phase extractions or as recognition elements for selective sensors. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：211 / 217

页数：7

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