Influence of retinoic acid and of cyclic AMP on the expression of choline acetyltransferase and of vesicular acetylcholine transporter in NG108-15 cells

被引：14

作者：

Diebler, MF

Tomasi, M

Meunier, FM

Israel, M ^{[1
]}

Dolezal, V

机构：

[1] CNRS, Neurobiol Cellulaire & Mol Lab, F-91190 Gif Sur Yvette, France

[2] CAS, Inst Physiol, Prague 14220, Czech Republic

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 5-6期

关键词：

choline acetyltransferase; vesicular acetylcholine transporter; NG108-15; retinoic acid; dbcAMP;

D O I：

10.1016/S0928-4257(99)80009-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Treatment of the cholinergic cell line NG108-15 with retinoic acid or cAMP results in an increase of choline acetyltransferase activity (ChAT) whereas none of these agents influences the amount of the vesicular acetylcholine transporter (VAChT) as judged from vesamicol binding and immunoblot studies. We suggest that immaturity of posttranslational events controlling the expression of VAChT protein is responsible for the apparent absence of coregulation of ChAT and VAChT protein expression. ((C) Elsevier, Paris).

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页码：379 / 384

页数：6

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