A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population

被引：12

作者：

Liguori, M

Sawcer, S

Setakis, E

Compston, A

Giordano, M

D'Alfonso, S

Mellai, M

Malferrari, G

Trojano, M

Livrea, P

De Robertis, F

Massacesi, L

Repice, A

Ballerini, C

Biagioli, T

Bomprezzi, R

Cannoni, S

Ristori, G

Salvetti, M

Grimaldi, LME

Biunno, I

Comi, G

Leone, M

Ferro, I

Naldi, P

Milanese, C

Gellera, C

Loredana, LM

Savettieri, G

Salemi, G

Aridon, P

Caputo, D

Guerini, FR

Ferrante, P

Momigliano-Richiardi, P

机构：

[1] Univ Piemonte Orientale, Lab Genet Umana, Dipartimento Sci Med, I-28100 Novara, Italy

[2] IRCAD, Novara, Italy

[3] Univ Bari, Dipartimento Sci Neurol & Psichiatriche, Bari, Italy

[4] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

[5] Inst Publ Hlth, MRC Biostat Unit, Cambridge, England

[6] Univ Milan, CISI, Ctr Interdisciplinare Studi Biomol & Applicaz Ind, Milan, Italy

[7] CNR, Ist Technol Biomed, I-20133 Milan, Italy

[8] Univ Florence, Dipartimento Sci Neurol & Psichiatriche, Florence, Italy

[9] Univ Roma La Sapienza, Dipartimento Sci Neurol, I-00185 Rome, Italy

[10] AUSL, Dipartimento Neurosci, Caltanissetta, Italy

[11] IRCCS, Dipartimento Neurosci, Milan, Italy

[12] Univ Osped San Raffaele, Milan, Italy

[13] Osped Maggiore La Carita, Clin Neurol, Novara, Italy

[14] Ist C Besta, Ctr SM, Milan, Italy

[15] Ist C Besta, Div Biochim & Genet, Milan, Italy

[16] Univ Palermo, Ist Neuropsicchiatria, Palermo, Italy

[17] IRCCS, Biol Lab, Fdn Gnocchi, Milan, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 143卷 / 1-2期

基金：

英国惠康基金;

关键词：

multiple sclerosis; whole genome linkage disequilibrium; microsatellites; DNA pools;

D O I：

10.1016/j.jneuroim.2003.08.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case-control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：97 / 100

页数：4

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