Activity of telithromycin against penicillin-resistant Streptococcus pneumoniae isolates recovered from French children with invasive and noninvasive infections

被引：5

作者：

Bingen, E

Doit, C

Loukil, C

Brahimi, N

Bidet, P

Deforche, D

Geslin, P

机构：

[1] Hop Robert Debre, Microbiol Serv, F-75019 Paris, France

[2] Hop Intercommunal Creteil, Microbiol Serv, Creteil, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 07期

关键词：

D O I：

10.1128/AAC.47.7.2345-2347.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We compared the activities of telithromycin, erythromycin, azithromycin, josamycin, penicillin G, amoxicillin, cefpodoxime, and ceftriaxone against invasive and noninvasive non-penicillin-susceptible Streptococcus pneumoniae isolates recovered from children. Of the 186 isolates tested, 89% were positive for erm(B) by PCR. Telithromycin had the lowest MICs, with MICs at which 90% of the isolates tested are inhibited of 0.032 and 0.25 mug/ml for erythromycin-sensitive and -resistant isolates, respectively.

引用

收藏

页码：2345 / 2347

页数：3

相关论文

共 34 条

[1] Macrolide resistance phenotypes and genotypes in French clinical isolates of Streptococcus pneumoniae [J].

Angot, P ;

Vergnaud, M ;

Auzou, M ;

Leclercq, R .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2000, 19 (10) :755-758

[2]

[Anonymous], 2002, M100S12 NCCLS

[3] Resistance among Streptococcus pneumoniae:: Implications for drug selection [J].

Appelbaum, PC .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (12) :1613-1620

[4] Ketolides - telithromycin, an example of a new class of antibacterial agents [J].

Bryskier, A .

CLINICAL MICROBIOLOGY AND INFECTION, 2000, 6 (12) :661-669

[5]

BRYSKIER A, 1999, ANTIBIOTIQUES AGENTS, P563

[6] Pharmacokinetic/pharmacodynamic parameters: Rationale for antibacterial dosing of mice and men [J].

Craig, WA .

CLINICAL INFECTIOUS DISEASES, 1998, 26 (01) :1-10

[7] Antipneumococcal activity of ABT-773 compared to those of 10 other agents [J].

Davies, TA ;

Ednie, LM ;

Hoellman, DM ;

Pankuch, GA ;

Jacobs, MR ;

Appelbaum, PC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (07) :1894-1899

[8] Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999-2000, including a comparison of resistance rates since 1994-1995 [J].

Doern, GV ;

Heilmann, KP ;

Huynh, HK ;

Rhomberg, PR ;

Coffman, SL ;

Brueggemann, AB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (06) :1721-1729

[9] Phenotypic and genetic diversity of invasive pneumococcal isolates recovered from French children [J].

Doit, C ;

Loukil, C ;

Geslin, P ;

Bingen, E .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (08) :2994-2998

[10] Molecular epidemiology survey of penicillin-susceptible and -resistant Streptococcus pneumoniae recovered from patients with meningitis in France [J].

Doit, C ;

Picard, B ;

Loukil, C ;

Geslin, P ;

Bingen, E .

JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (06) :1971-1978

← 1 2 3 4 →