Distribution and cellular localization of caldendrin immunoreactivity in adult human forebrain

被引：15

作者：

Bernstein, HG

Seidenbecher, CI

Smalla, KH

Gundelfinger, ED

Bogerts, B

Kreutz, MR

机构：

[1] Leibniz Inst Neurobiol, Dept Neurochem Mol Biol, AG Mol Mech Plast, D-39118 Magdeburg, Germany

[2] Univ Magdeburg, Dept Psychiat, D-39106 Magdeburg, Germany

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 2003年 / 51卷 / 08期

关键词：

EF-hand proteins; dendrites; axons; pyramidal cells; interneuron; calcium-binding protein; calmodulin;

D O I：

10.1177/002215540305100816

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We investigated by immunohistochemistry (IHC) the distribution of caldendrin, the founding member of a novel family of neuronal calcium-binding proteins closely related to calmodulin, in human forebrain. Caldendrin immunoreactivity was unevenly distributed, with prominent staining in the paleo- and neocortex, hippocampus, and hypothalamus. With the exception of the hypothalamus, labeling was restricted to the somato-dendritic compartment of neurons. This distribution completely matches that reported in rat, indicating that the cellular function is most likely conserved among species. Therefore, one prerequisite for functional studies in rodent models aimed at elucidation of mechanisms with relevance for humans can be based on the present findings.

引用

页码：1109 / 1112

页数：4

共 12 条

[1]

Bernstein C, 1999, STAND MAG, V1, P28

[2] Nitric oxide synthase-containing neurons in the human hypothalamus: Reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics [J].