Laser immunotherapy - A novel treatment modality for metastatic tumors

被引：74

作者：

Chen, WR

Carubelli, R

Liu, H

Nordquist, RE

机构：

[1] Univ Cent Oklahoma, Biomed Engn Program, Dept Phys & Engn, Edmond, OK 73034 USA

[2] Univ Oklahoma, Dept Phys & Astron, Norman, OK 73109 USA

[3] Wound Healing Oklahoma Inc, Oklahoma City, OK 73105 USA

[4] Univ Oklahoma, Ctr Bioengn, Norman, OK 73109 USA

[5] Univ Oklahoma, Sch Elect & Comp Engn, Norman, OK 73109 USA

来源：

MOLECULAR BIOTECHNOLOGY | 2003年 / 25卷 / 01期

关键词：

near-infrared laser; indocyanine green; glycated chitosan; DMBA-4; metastatic rat tumor; photothermal laser tissue interaction; immunological stimulation; laser immunotherapy;

D O I：

10.1385/MB:25:1:37

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Laser immunotherapy is a novel approach for the treatment of metastatic tumors. It combines a selective photothermal laser-tissue interaction for direct tumor destruction and an immunoadjuvant-directed simulation for immune responses. In experiments using a rat metastatic tumor model, laser immunotherapy resulted in the eradication of-both, treated primary tumors and untreated metastases at remote sites. It also induced anti-tumor resistance.

引用

页码：37 / 43

页数：7

共 18 条

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Anghileri LJ, 1986, HYPERTHERMIA CANC TR

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BOULNOIS J-L, 1986, Lasers in Medical Science, V1, P47, DOI 10.1007/BF02030737

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