Toll-like receptor 7 mediates pruritus

被引：190

作者：

Liu, Tong ^{[1
,2
]}

Xu, Zhen-Zhong ^{[1
,2
]}

Park, Chul-Kyu ^{[1
,2
]}

Berta, Temugin ^{[1
,2
]}

Ji, Ru-Rong ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Sensory Plast Lab, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 12期

基金：

美国国家卫生研究院;

关键词：

ITCH SENSATION; INFLAMMATION; ACTIVATION; PAIN;

D O I：

10.1038/nn.2683

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Toll-like receptors are typically expressed in immune cells to regulate innate immunity. We found that functional Toll-like receptor 7 (TLR7) was expressed in C-fiber primary sensory neurons and was important for inducing itch (pruritus), but was not necessary for eliciting mechanical, thermal, inflammatory and neuropathic pain in mice. Our results indicate that TLR7 mediates itching and is a potential therapeutic target for anti-itch treatment in skin disease conditions.

引用

页码：1460 / 1462

页数：3

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