Carbonates: eco-friendly solvents for palladium-catalysed direct arylation of heteroaromatics

被引：99

作者：

Dong, Jia Jia ^{[1
]}

Roger, Julien ^{[1
]}

Verrier, Cecile ^{[2
,3
]}

Martin, Thibaut ^{[2
,3
]}

Le Goff, Ronan ^{[1
]}

Hoarau, Christophe ^{[2
,3
]}

Doucet, Henri ^{[1
]}

机构：

[1] Univ Rennes 1 Catalyse & Organometall, CNRS, Inst Sci Chim Rennes, UMR 6226, F-35042 Rennes, France

[2] Univ Rouen, F-76131 Mont St Aignan, France

[3] INSA, CNRS, Inst Chim Organ Fine IRCOF Associee, UMR 6014, F-76131 Mont St Aignan, France

来源：

GREEN CHEMISTRY | 2010年 / 12卷 / 11期

关键词：

DIRECT C-2 ARYLATION; INCLUDING FREE (NH)-IMIDAZOLE; CROSS-COUPLING REACTIONS; C-H FUNCTIONALIZATION; DIMETHYL CARBONATE; ROOM-TEMPERATURE; ARYL HALIDES; REGIOSELECTIVE SYNTHESIS; ALTERNATIVE SOLVENTS; PROPYLENE CARBONATE;

D O I：

10.1039/c0gc00229a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The palladium-catalysed direct 2-, 4- or 5-arylation of a wide range of heteroaromatics with aryl halides proceed in moderate to good yields using the eco-friendly solvents carbonates. The best yields were obtained using benzoxazole or thiazole derivatives. The arylation of furan, thiophene, pyrrole, imidazole or isoxazole derivatives was found to require a more elevated reaction temperature.

引用

页码：2053 / 2063

页数：11

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