Vasopeptidase inhibitors: an emerging class of cardiovascular drugs

被引：45

作者：

Bralet, J ^{[1
]}

Schwartz, JC

机构：

[1] Univ Dijon, Fac Pharm, F-21033 Dijon, France

[2] INSERM, Ctr Paul Broca, Inst Univ France, F-75014 Paris, France

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 03期

关键词：

D O I：

10.1016/S0165-6147(00)01644-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vasopeptidase inhibitors (VPIs) inhibit both angiotensin-converting enzyme (ACE) and neprilysin (NEP) and can thus reduce the activity of the renin-angiotensin system and potentiate the vasodilatory, natriuretic and antiproliferative effects of bradykinin and natriuretic peptides, In preclinical studies, VPIs display a large profile being effective in all tested models of hypertension and in heart failure, and ongoing clinical studies suggest th at VPIs possess advantages over other therapies.

引用

页码：106 / 109

页数：6

共 26 条

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