Vasopeptidase inhibitors: an emerging class of cardiovascular drugs

被引：45

作者：

Bralet, J ^{[1
]}

Schwartz, JC

机构：

[1] Univ Dijon, Fac Pharm, F-21033 Dijon, France

[2] INSERM, Ctr Paul Broca, Inst Univ France, F-75014 Paris, France

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 03期

关键词：

D O I：

10.1016/S0165-6147(00)01644-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vasopeptidase inhibitors (VPIs) inhibit both angiotensin-converting enzyme (ACE) and neprilysin (NEP) and can thus reduce the activity of the renin-angiotensin system and potentiate the vasodilatory, natriuretic and antiproliferative effects of bradykinin and natriuretic peptides, In preclinical studies, VPIs display a large profile being effective in all tested models of hypertension and in heart failure, and ongoing clinical studies suggest th at VPIs possess advantages over other therapies.

引用

页码：106 / 109

页数：6

共 26 条

[21] A randomized trial of ecadotril versus placebo in patients with mild to moderate heart failure: The US Ecadotril Pilot Safety Study
O'Connor, CM
Gattis, WA
Gheorghiade, M
Granger, CB
Gilbert, J
McKenney, JM
Messineo, FC
Burnett, JC
Katz, SD
Elkayam, U
Kasper, EK
Goldstein, S
Cody, RJ
Massie, BM
[J]. AMERICAN HEART JOURNAL, 1999, 138 (06) : 1140 - 1148
[22] ROBL JA, 1997, ANTIHYPERTENSIVE DRU, P113
[23] Comparison of vasopeptidase inhibitor, omapatrilat, and lisinopril on exercise tolerance and morbidity in patients with heart failure: IMPRESS randomised trial
Rouleau, JL
Pfeffer, MA
Stewart, DJ
Isaac, D
Sestier, F
Kerut, EK
Porter, CB
Proulx, G
Qian, CL
Block, AJ
[J]. LANCET, 2000, 356 (9230) : 615 - 620
[24] Vasopeptidase inhibition with omapatrilat improves cardiac geometry and survival in cardiomyopathic hamsters more than does ACE inhibition with captopril
Trippodo, NC
Fox, M
Monticello, TM
Panchal, BC
Asaad, MM
[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1999, 34 (06) : 782 - 790
[25] Combined inhibition of neutral endopeptidase and angiotensin-converting enzyme by sampatrilat in essential hypertension
Wallis, EJ
Ramsay, LE
Hettiarachchi, J
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1998, 64 (04) : 439 - 449
[26] Weber M, 1999, AM J HYPERTENS, V12, p139S

← 1 2 3 →