共 67 条
ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER
被引:102
作者:

Bernasconi, Riccardo
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Res Biomed, CH-6500 Bellinzona, Switzerland Inst Res Biomed, CH-6500 Bellinzona, Switzerland

Molinari, Maurizio
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Res Biomed, CH-6500 Bellinzona, Switzerland
Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland Inst Res Biomed, CH-6500 Bellinzona, Switzerland
机构:
[1] Inst Res Biomed, CH-6500 Bellinzona, Switzerland
[2] Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
基金:
瑞士国家科学基金会;
关键词:
RETICULUM-ASSOCIATED DEGRADATION;
UNFOLDED PROTEIN RESPONSE;
UBIQUITIN LIGASE COMPLEX;
ENDOPLASMIC-RETICULUM;
QUALITY-CONTROL;
MANNOSIDASE-I;
MUTANT ALPHA-1-ANTITRYPSIN;
GLYCOPROTEIN DEGRADATION;
MISFOLDED PROTEINS;
EDEM1;
D O I:
10.1016/j.ceb.2010.10.002
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins in eukaryotic cells. Unsuccessful folding attempts are eventually interrupted and most folding-defective polypeptides are dislocated across the ER membrane and degraded by cytosolic proteasomes in a complex series of events collectively defined as ER-associated degradation (ERAD). Uncontrolled ERAD activity might prematurely interrupt ongoing folding programs. At steady state, this is prevented by ERAD tuning, that is, the removal of select ERAD regulators from the ER and their degradation by proteasomes and by endo-lysosomal proteases. In Coronaviruses infected cells, the formation of LC3-I coated vesicles containing ERAD regulators cleared from the ER lumen is co-opted to anchor viral replication and transcription complexes to ER-derived membranes.
引用
收藏
页码:176 / 183
页数:8
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