Synthesis and study of an acridine substituted Troger's base:: preferential binding of the (-)-isomer to B-DNA

被引:96
作者
Tatibouët, A
Demeunynck, M
Andraud, C
Collet, A
Lhomme, J
机构
[1] Univ Grenoble 1, Etud Dynam & Struct Select Lab, CNRS, UMR 5616, F-38041 Grenoble, France
[2] Ecole Normale Super Lyon, CNRS, UMR 117, F-69364 Lyon 07, France
关键词
D O I
10.1039/a808822e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The acridine substituted Troger's base 4 was prepared, resolved and the (-)-(7R,17R) enantiomer was shown to bind preferentially to calf-thymus B-DNA.
引用
收藏
页码:161 / 162
页数:2
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