Recent trends in electrochemical DNA biosensor technology

被引：264

作者：

Kerman, K ^{[1
]}

Kobayashi, M ^{[1
]}

Tamiya, E ^{[1
]}

机构：

[1] Japan Adv Inst Sci & Technol, Sch Mat Sci, Tatsunokuchi, Ishikawa 9231292, Japan

来源：

MEASUREMENT SCIENCE AND TECHNOLOGY | 2004年 / 15卷 / 02期

关键词：

electrochemical DNA hybridization biosensor; transduction of DNA hybridization; DNA recognition interface; redox-labels; label-free detection; metal nanoparticles; electrical detection;

D O I：

10.1088/0957-0233/15/2/R01

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Recent trends and challenges in the electrochemical methods for the detection of DNA hybridization are reviewed. Electrochemistry has superior properties over the other existing measurement systems, because electrochemical biosensors can provide rapid, simple and low-cost on-field detection. Electrochemical measurement protocols are also suitable for mass fabrication of miniaturized devices. Electrochemical detection of hybridization is mainly based on the differences in the electrochemical behaviour of the labels towards the hybridization reaction on the electrode surface or in the solution. Basic criteria for electrochemical DNA biosensor technology, and already commercialized products, are also introduced. Future prospects towards PCR-free DNA chips are discussed.

引用

页码：R1 / R11

页数：11

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