Emergence, mechanism, and clinical implications of reduced glycopeptide susceptibility in Staphylococcus aureus

被引:38
作者
Geisel, R
Schmitz, FJ
Fluit, AC
Labischinski, H
机构
[1] Univ Dusseldorf, Inst Med Mikrobiol & Virol, D-40225 Dusseldorf, Germany
[2] Univ Utrecht, Med Ctr, Inst Med Microbiol, Utrecht, Netherlands
[3] Bayer AG, PH Res Antiinfect, D-5600 Wuppertal, Germany
关键词
D O I
10.1007/s100960100595
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
In order to understand the mechanism(s) of the resistance/reduced susceptibility of Staphylococcus aureus to glycopeptide antibiotics, the current data on the modes of action of glycopeptides were reviewed. In addition, the different test systems for detecting vancomycin resistance and the clinical relevance of resistant Staphylococcus aureus were analyzed. Finally, strategies to prevent the nosocomial spread of these bacteria are presented, as are new therapeutic options.
引用
收藏
页码:685 / 697
页数:13
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共 68 条
[41]   CHEMICAL BASIS FOR ACTION OF VANCOMYCIN GROUP OF ANTIBIOTICS [J].
PERKINS, HR ;
NIETO, M .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1974, 235 (MAY10) :348-363
[42]   Characterization of passage-selected vancomycin-resistant Staphylococcus aureus strains of diverse parental backgrounds [J].
Pfeltz, RF ;
Singh, VK ;
Schmidt, JL ;
Batten, MA ;
Baranyk, CS ;
Nadakavukaren, MJ ;
Jayaswal, RK ;
Wilkinson, BJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (02) :294-303
[43]   First clinical isolate of vancomycin-intermediate Staphylococcus aureus in a French hospital [J].
Ploy, MC ;
Grélaud, C ;
Martin, C ;
de Lumley, L ;
Denis, F .
LANCET, 1998, 351 (9110) :1212-1212
[44]   Alternatives to vancomycin in treating methicillin-resistant Staphylococcus aureus infections [J].
Rahman, M .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 41 (03) :325-328
[46]   Staphylococcus aureus with reduced susceptibility to vancomycin isolated from a patient with fatal bacteremia [J].
Rotun, SS ;
McMath, V ;
Schoonmaker, DJ ;
Maupin, PS ;
Tenover, FC ;
Hill, BC ;
Ackman, DM .
EMERGING INFECTIOUS DISEASES, 1999, 5 (01) :147-149
[47]   EFFICIENT DETECTION AND LONG-TERM PERSISTENCE OF THE CARRIAGE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS [J].
SANFORD, MD ;
WIDMER, AF ;
BALE, MJ ;
JONES, RN ;
WENZEL, RP .
CLINICAL INFECTIOUS DISEASES, 1994, 19 (06) :1123-1128
[48]   Susceptibility of 302 methicillin-resistant Staphylococcus aureus isolates from 20 European university hospitals to vancomycin and alternative antistaphylococcal compounds [J].
Schmitz, FJ ;
Krey, A ;
Geisel, R ;
Verhoef, J ;
Heinz, HP ;
Fluit, AC .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1999, 18 (07) :528-530
[49]   TEICOPLANIN-RESISTANT STAPHYLOCOCCUS-AUREUS EXPRESSES A NOVEL MEMBRANE-PROTEIN AND INCREASES EXPRESSION OF PENICILLIN-BINDING PROTEIN-2 COMPLEX [J].
SHLAES, DM ;
SHLAES, JH ;
VINCENT, S ;
ETTER, L ;
FEY, PD ;
GOERING, RV .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (11) :2432-2437
[50]   Gradual alterations in cell wall structure and metabolism in vancomycin-resistant mutants of Staphylococcus aureus [J].
Sieradzki, K ;
Tomasz, A .
JOURNAL OF BACTERIOLOGY, 1999, 181 (24) :7566-7570