Molecular analysis of relapse vs re-infection in HIV-positive patients suffering from recurrent Clostridium difficile associated diarrhoea

被引：28

作者：

Alonso, R ^{[1
]}

Gros, S ^{[1
]}

Peláez, T ^{[1
]}

García-de-Viedma, D ^{[1
]}

Rodríguez-Créixems, M ^{[1
]}

Bouza, E ^{[1
]}

机构：

[1] Hosp Gen Univ Gregorio Maranon, Serv Microbiol & Enfermedades Infecciosas, Madrid 28007, Spain

来源：

JOURNAL OF HOSPITAL INFECTION | 2001年 / 48卷 / 02期

关键词：

Clostridium difficile; HIV; recurrences; RAPD; typing;

D O I：

10.1053/jhin.2001.0943

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Recurrence is a major complication of Clostridium difficile associated diarrhoea, especially in human immunodeficiency virus (HIV) positive patients, and it is important to distinguish between relapse and re-infection in recurrent episodes. The aim of our study was to analyse C. difficile isolates obtained from HIV-positive patients with recurrent diarrhoea in order to distinguish between relapse and re-infection. This analysis was based on the study of DNA similarities among isolates obtained from different episodes within each patient. Relapses occurred in 64% of patients, 32% suffered re-infections and a combination of relapse plus re-infection was seen in 4%. DNA typing methods can be useful tools to characterize recurrent episodes of C. difficile associated disease. (C) 2001 The Hospital infection Society.

引用

页码：86 / 92

页数：7

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