The palmoplantar keratodermas: much more than palms and soles

被引：50

作者：

Kelsell, DP ^{[1
]}

Stevens, HP ^{[1
]}

机构：

[1] St Bartholomews & Royal London Hosp, Ctr Cutaneous Biol, London E1 2AT, England

来源：

MOLECULAR MEDICINE TODAY | 1999年 / 5卷 / 03期

关键词：

D O I：

10.1016/S1357-4310(98)01428-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inherited palmoplantar keratodermas (PPKs) are a diverse and often clinically confusing branch of the genetic skin diseases. As the name suggests, the lesions of PPK primarily affect the palms and soles of the feet, although a number of the PPKs are also associated with a genetic predisposition to other conditions, including cancer, hearing loss and heart failure, The mapping and identification of genes that underlie the PPKs reveal new insights into the biological interactions of the structural components of the palmoplantar epidermis and further our understanding of epidermal disease. More significantly, by genetically characterizing the PPKs, genes that have a role in life-threatening disorders might also be identified.

引用

页码：107 / 113

页数：7

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