Participation of adenosine receptors in neuroprotection

被引：69

作者：

Ribeiro, JA ^{[1
]}

Sebastiao, AM ^{[1
]}

de Mendonça, A ^{[1
]}

机构：

[1] Univ Lisbon, Neurosci Lab, Fac Med, P-1649028 Lisbon, Portugal

来源：

DRUG NEWS & PERSPECTIVES | 2003年 / 16卷 / 02期

关键词：

D O I：

10.1358/dnp.2003.16.2.740246

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adenosine is released from most cells, including neurons and glial cells. Once in the extracellular space, adenosine modifies cell functioning by operating G-protein-coupled receptors. Interaction between adenosine receptors and other receptors for neuromodulators might contribute to a fine tuning of neuronal function, and therefore, to neuroprotection. Manipulation of adenosine receptors may influence sleep and arousal, cognition and memory, neuronal damage and degeneration and neuronal maturation. The therapeutic implications for neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy and multiple sclerosis are discussed. (C) 2003 Prous Science. All rights reserved.

引用

页码：80 / 86

页数：7

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