Increase of lipid hydroperoxides in the rat liver and kidney after administering ferric nitrilotriacetate

被引：25

作者：

Ikeda, K

Sun, F

Tanaka, K

Tokumaru, S

Kojo, S ^{[1
]}

机构：

[1] Nara Womens Univ, Dept Food Sci & Nutr, Nara 6308506, Japan

[2] Joetsu Univ Educ, Niigata 9438512, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1998年 / 62卷 / 07期

关键词：

ferric nitrilotriacetate; hydroperoxide; lipid peroxidation; radical reaction; iron overload;

D O I：

10.1271/bbb.62.1438

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two hours after an intraperitoneal injection of ferric nitrilotriacetate to rats at a dose of 15 mg of Fe/kg of body weight, the level of lipid hydroperoxides, which was determined by a specific method involving chemical conversion into 1-naphthyldiphenylphosphine oxide and HPLC, had increased significantly in the liver (from 190.1+/-58.8 of the control to 467.1+/-175.8 pmol/mg of protein) and kidney (from 181.8+/-52.3 of the control to 405.9+/-22.7 pmol/mg of protein). These results demonstrate that oxidative stress was transiently increased by an iron overload in these tissues.

引用

页码：1438 / 1439

页数：2

共 24 条

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