Effect of fasting on insulin receptor-related receptor messenger ribonucleic acid in rat kidney

被引：8

作者：

Chrysis, D ^{[1
]}

Moats-Staats, BM ^{[1
]}

Underwood, LE ^{[1
]}

机构：

[1] Univ N Carolina, Dept Pediat, Div Endocrinol, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF ENDOCRINOLOGY | 1998年 / 159卷 / 02期

关键词：

D O I：

10.1677/joe.0.159R009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The insulin receptor-related receptor (IRR), a member of the insulin receptor tyrosine kinase family, has structural homology to the insulin receptor (LR) and the IGF-I receptor (IGF-IR). The ligand, gene regulation and biological function of the IRR are not known. Because mRNAs for both the IR and IGF-IR are increased by nutrient restriction, we used RNase protection assays to assess the effects of fasting 48 h on IRR mRNA in kidneys of rats. We compared the changes in IRR with those in IR and IGF-IR mRNAs. We observed a significant increase in steady state levels of IRR (ratio of IRR mRNA to B-actin in fed vs fasted animals, 0.59+/-0.1 and 1.25+/-0.14 respectively, P<0.01), suggesting that the ligand for IRR also might be regulated by nutrients.

引用

页码：R9 / R12

页数：4

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