Mitochondria - A nexus for aging, calorie restriction, and sirtuins?

被引：404

作者：

Guarente, Leonard ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CELL | 2008年 / 132卷 / 02期

关键词：

D O I：

10.1016/j.cell.2008.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.

引用

页码：171 / 176

页数：6

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