The inflammatory Th 17 subset in immunity against self and non-self antigens

被引：43

作者：

Jin, Di ^{[1
,3
]}

Zhang, Lianjun ^{[1
,3
]}

Zheng, Jialin ^{[2
,3
]}

Zhao, Yong ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Inst Zool, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China

[2] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Lab Neurotoxicol, Omaha, NE USA

[3] China US foint Res Ctr Med Sci & Genet, Beijing, Peoples R China

来源：

AUTOIMMUNITY | 2008年 / 41卷 / 02期

关键词：

CD4(+) T cells; Th17; cells; regulatory T cells; immune regulation;

D O I：

10.1080/08916930701776605

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper cells (Th cells) are traditionally thought to differentiate into Th1 and Th2 subsets based on their cytokine profiles. Recently, a subset of interleukin (IL)-17-producing cells (Th17 cells) which develop and function in a distinct way from Th1 or Th2 cells has been identified. Th17 cells have been shown to play a crucial role in the induction of autoimmune tissue injuries, inflammation and infection. Studies on Th17 subset and its relevant issues offered potential therapeutic targets for patients with autoimmune diseases, cancer, infection and transplant, which may have significant impacts in the prevention and/or treatment of immunity-related diseases in clinics.

引用

收藏

页码：154 / 162

页数：9

相关论文

共 95 条

[11] Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi [J].

Burchill, MA ;

Nardelli, DT ;

England, DM ;

DeCoster, DJ ;

Christopherson, JA ;

Callister, SM ;

Schell, RF .

INFECTION AND IMMUNITY, 2003, 71 (06) :3437-3442

[12] FOXP3 modifies the phenotypic and functional properties of regulatory T cells [J].

Campbell, Daniel J. ;

Ziegler, Steven F. .

NATURE REVIEWS IMMUNOLOGY, 2007, 7 (04) :305-310

[13] Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis [J].

Chen, Y ;

Langrish, CL ;

Mckenzie, B ;

Joyce-Shaikh, B ;

Stumhofer, JS ;

McClanahan, T ;

Blumenschein, W ;

Churakovsa, T ;

Low, J ;

Presta, L ;

Hunter, CA ;

Kastelein, RA ;

Cua, DJ .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (05) :1317-1326

[14] Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells [J].

Chen, Zhi ;

Laurence, Arian ;

Kanno, Yuka ;

Pacher-Zavisin, Margit ;

Zhu, Bing-Mei ;

Tato, Cristina ;

Yoshimura, Akihiko ;

Hennighausen, Lothar ;

O'Shea, John J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (21) :8137-8142

[15]

CHI W, 2007, J ALLERGY CLIN

[16] Failure to suppress the expansion of the activated CD4 T cell population in interferon γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis [J].

Chu, CQ ;

Wittmer, S ;

Dalton, DK .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (01) :123-128

[17] Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain [J].

Cua, DJ ;

Sherlock, J ;

Chen, Y ;

Murphy, CA ;

Joyce, B ;

Seymour, B ;

Lucian, L ;

To, W ;

Kwan, S ;

Churakova, T ;

Zurawski, S ;

Wiekowski, M ;

Lira, SA ;

Gorman, D ;

Kastelein, RA ;

Sedgwick, JD .

NATURE, 2003, 421 (6924) :744-748

[18] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene [J].

Duerr, Richard H. ;

Taylor, Kent D. ;

Brant, Steven R. ;

Rioux, John D. ;

Silverberg, Mark S. ;

Daly, Mark J. ;

Steinhart, A. Hillary ;

Abraham, Clara ;

Regueiro, Miguel ;

Griffiths, Anne ;

Dassopoulos, Themistocles ;

Bitton, Alain ;

Yang, Huiying ;

Targan, Stephan ;

Datta, Lisa Wu ;

Kistner, Emily O. ;

Schumm, L. Philip ;

Lee, Annette T. ;

Gregersen, Peter K. ;

Barmada, M. Michael ;

Rotter, Jerome I. ;

Nicolae, Dan L. ;

Cho, Judy H. .

SCIENCE, 2006, 314 (5804) :1461-1463

[19] CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation [J].

Ehirchiou, Driss ;

Xiong, Ying ;

Xu, Guangwu ;

Chen, Wanjun ;

Shi, Yufang ;

Zhang, Li .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (07) :1519-1524

[20] IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger [J].

Ferretti, S ;

Bonneau, O ;

Dubois, GR ;

Jones, CE ;

Trifilieff, A .

JOURNAL OF IMMUNOLOGY, 2003, 170 (04) :2106-2112

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